- American's hub for the southeastern United States and secondary Caribbean gateway. Its operations in Concourse E are the largest regional flight operation in the world. American has about 90% of the market share at CLT, making it the largest carrier at the airport. It is a former hub which it inherited from
- – American's hub for the Midwest. American has about 30% of the market share at O'Hare, making it the airport's second largest airline after .
- – American's hub for the southern United States and largest hub overall. American currently has about 85% of the market share at DFW, making it the largest carrier
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- https://developer-community.sage.com/topic/13942-frontier~airline%E2%84%A2-does-frontier-give-you-a-refund%E2%8A%99_%E2%8A%99faqs%E2%84%A2%EF%B8%8Fservice/
- https://developer-community.sage.com/topic/13942-frontier~airline%E2%84%A2-does-frontier-give-you-a-refund%E2%8A%99_%E2%8A%99faqs%E2%84%A2%EF%B8%8Fservice/
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- at the airport. American's corporate headquarters are also in Fort Worth near the airport. DFW serves as American's primary Transpacific hub, primary gateway to Mexico and its secondary gateway to Latin America.
- – American's hub for the West Coast and secondary transpacific gateway. Though American has increasingly reduced its network out of Los Angeles, citing many long-haul international routes as unprofitable, it still maintains a limited amount of transatlantic and transpacific flights.
- – American's primary Latin American and Caribbean hub. American has about 68% of the market share in Miami, making it the largest airline at the airport.
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